Drawn to Bigger Things

Bigger and better things.

Parasite genomics—Time to think bigger

It has been more than 20 years since genomics approaches began to be applied to the problem of tropical neglected parasitic diseases in the form of pilot genome sequencing projects. The Plasmodium falciparum genome sequence was published in 2002 [1] as the result of an international collaborative effort, and the first reference genome sequences of Trypanosoma cruzi, Trypanosoma brucei and Leish...

The bigger picture concepts

If a concept is not well defined, it can be abused. This is particularly true of complexity, an inherently interdisciplinary concept that has penetrated a range of intellectual fields from physics to linguistics, but with no underlying, unified theory. Complexity has become a popular buzzword that is used in the hope of gaining attention or funding — institutes and research networks associated ...

Is Bigger Really Badder?

Increasing attention is being focused on the role(s) that obesity may play in the development of cardiovascular disease, particularly congestive heart failure (CHF).1,2 Several indirect or associated effects are potential culprits. For example, obesity is strongly associated with many atherosclerotic risk factors, including arterial hypertension, insulin resistance, diabetes, and dyslipidemia.3...

Learning to Order Things

There are many applications in which it is desirable to order rather than classify instances. Here we consider the problem of learning how to order, given feedback in the form of preference judgments, i.e., statements to the effect that one instance should be ranked ahead of another. We outline a two-stage approach in which one first learns by conventional means a preference function, of the fo...